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Article

VHL down-regulation and differential localization as mechanisms in tumorigenesis.

Kidney international - 1 Nov 2003

Shiao Yih-Horng, Forsti Asta, Egevad Lars, Anderson Lucy M, Lindblad Per, Hemminki Kari

Abstract excerpt

BACKGROUND: The von Hippel-Lindau (VHL) gene has been widely analyzed in many tumors. Early studies in animal tumors suggest that changes in VHL protein level and localization may be also important in tumorigenesis. In this study, we determined the role of VHL protein in human renal cell carcinomas. METHODS: Seventy-five human renal cell carcinomas, predominantly of clear cell type (60 of 75), were examined for...

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Source

Identifiers

PMID: 14531799
DOI: 10.1046/j.1523-1755.2003.00257.x

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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