The von Hippel-Lindau tumor suppressor gene. A rare and intriguing disease opening new insight into basic mechanisms of carcinogenesis.

doi:10.1016/s0165-4608(96)00296-8

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Article

The von Hippel-Lindau tumor suppressor gene. A rare and intriguing disease opening new insight into basic mechanisms of carcinogenesis.

Cancer genetics and cytogenetics - 1 Jan 1997

Decker H J, Weidt E J, Brieger J

Abstract excerpt

The von Hippel-Lindau (VHL) disease is an inherited tumor susceptibility syndrome featuring a high variety of benign and malignant tumors. The gene has been localized and cloned at 3p25-26. Recent functional analysis defined the VHL gene product as an inhibitor of the transcription elongation pro...

Topics

Adult
Brain Neoplasms
Carcinoma, Renal Cell
Chromosome Mapping
Chromosomes, Human, Pair 3
Female
Genes, Tumor Suppressor
Genotype
Germ-Line Mutation
Hemangioblastoma
Humans
Kidney Neoplasms
Ligases
Male
Neovascularization, Pathologic
Phenotype
Proteins
Retina

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Open in PubMed

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PMID: 9062583
DOI: 10.1016/s0165-4608(96)00296-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9062583-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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