Article

Rescuing the Function of Missense-Mutated Tumor Suppressor <i>VHL</i> using Stabilizing Small Molecules

2026-01-02

Abstract excerpt

<h4>Summary</h4> Somatic mutations in the VHL gene, coupled with VHL loss of heterozygosity, drive sporadic clear cell renal cell carcinoma (ccRCC). From structural considerations, we hypothesized that certain mutations in the VHL gene thermodynamically destabilize the folded protein product; these mutations would increase the ratio of unfolded:folded pVHL, and thus cause loss of function. To test this, we use...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ff4ab675-e668-506f-83da-c35b40c84fc5
DOI: 10.64898/2026.01.02.697373

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rescuing the Function of Missense-Mutated Tumor Suppressor <i>VHL</i> using Stabilizing Small MoleculesDOI 10.64898/2026.01.02.697373Read

Characterizing and predicting ccRCC-causing missense mutations in Von Hippel-Lindau diseaseSemantic proximity Read

Characterization of VHL missense mutations in sporadic clear cell renal cell carcinoma: hotspots, affected binding domains, functional impact on pVHL and therapeutic relevanceSemantic proximity Read

The von Hippel-Lindau geneSemantic proximity Read

VHL missense mutation delineate aggressive clear cell renal cell carcinoma subtype with favorable immunotherapeutic responseSemantic proximity Read

Strategies for in Silico Drug Discovery to Modulate Macromolecular Interactions Altered by Mutations.Semantic proximity Read

Structural bioinformatics mutation analysis reveals genotype-phenotype correlations in von Hippel-Lindau disease and suggests molecular mechanisms of tumorigenesis.Semantic proximity Read

Natural (and Unnatural) Small Molecules as Pharmacological Chaperones and Inhibitors in Cancer.Semantic proximity Read

Mechanisms of resistance to VHL loss-induced genetic and pharmacological vulnerabilitiesSemantic proximity Read

VHL, the story of a tumour suppressor gene.Semantic proximity Read

Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations.Semantic proximity Read

High-throughput simultaneous screen and counterscreen identifies homoharringtonine as synthetic lethal with von Hippel-Lindau loss in renal cell carcinomaSemantic proximity Read

Saturation Genome Editing Resolves the Functional Spectrum of Pathogenic <i>VHL</i> AllelesSemantic proximity Read