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Article

A new tumor suppressor role for the Notch pathway in bladder cancer.

Nature medicine - 1 Oct 2014

Rampias Theodoros, Vgenopoulou Paraskevi, Avgeris Margaritis, Polyzos Alexander, Stravodimos Konstantinos, Valavanis Christos, Scorilas Andreas, Klinakis Apostolos

Abstract excerpt

The Notch signaling pathway controls cell fates through interactions between neighboring cells by positively or negatively affecting the processes of proliferation, differentiation and apoptosis in a context-dependent manner. This pathway has been implicated in human cancer as both an oncogene and a tumor suppressor. Here we report new inactivating mutations in Notch pathway components in over 40% of human...

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Source

Identifiers

PMID: 25194568
DOI: 10.1038/nm.3678

Genes

FGFR3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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