Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct immune responses to transgene products from rAAV1 and rAAV8 vectors

22 Sept 2009

Abstract excerpt

Recently developed serotypes of recombinant adeno-associated virus (rAAV) vectors have significantly enhanced the use of rAAV vectors for gene therapy. However, host immune responses to the transgene products from different serotypes remain uncharacterized. In the present study, we evaluated the differential immune responses to the transgene products from rAAV1 and rAAV8 vectors. In non-obese diabetic (NOD) mice,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Viral Infectious Diseases and Gene Expression in Insects
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19805176
DOI: 10.1073/pnas.0909520106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct immune responses to transgene products from rAAV1 and rAAV8 vectorsPMID 19805176Read ↗

Challenges Posed by Immune Responses to AAV Vectors: Addressing Root CausesSemantic proximity Read ↗

Understanding and Tackling Immune Responses to Adeno-Associated Viral VectorsSemantic proximity Read ↗

Adenoviral Vector Immunity: Its Implications and Circumvention StrategiesSemantic proximity Read ↗

Assessment of Humoral, Innate, and T-Cell Immune Responses to Adeno-Associated Virus VectorsSemantic proximity Read ↗

Early Interaction of Adeno-Associated Virus Serotype 8 Vector with the Host Immune System Following Intramuscular Delivery Results in Weak but Detectable Lymphocyte and Dendritic Cell TransductionSemantic proximity Read ↗

Innate Immune Sensing of Adeno-Associated Virus VectorsSemantic proximity Read ↗

Immune Recognition of Gene Transfer Vectors: Focus on Adenovirus as a ParadigmSemantic proximity Read ↗

The Complex and Evolving Story of T cell Activation to AAV Vector-encoded Transgene ProductsSemantic proximity Read ↗

Recombinant adeno-associated virus vectors induce functionally impaired transgene product–specific CD8+ T cells in miceSemantic proximity Read ↗

The TLR9-MyD88 pathway is critical for adaptive immune responses to adeno-associated virus gene therapy vectors in miceSemantic proximity Read ↗

The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9–dependent innate immune responses in the liverSemantic proximity Read ↗

<i>α</i> <sub>1</sub> -Antitrypsin Gene Therapy Modulates Cellular Immunity and Efficiently Prevents Type 1 Diabetes in Nonobese Diabetic MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.