Article
CD82, member of the tetra-span-transmembrane protein family, is a costimulatory protein for T cell activation.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 1995
Lebel-Binay S, Lagaudrière C, Fradelizi D, Conjeaud H
Abstract excerpt
It is now well documented that full activation of T cells requires a two-signal triggering that can be mimicked, in the absence of accessory cells, by co-immobilization of mAbs directed to stimulatory/accessory molecules (CD2, CD3, CD28, adhesion molecules, etc.). In this report, we describe that engagement of CD82 can delivery such a costimulatory signal for full activation of the human T cell line Jurkat,...
Topics
- Antibodies
- Antibodies, Monoclonal
- Antigens, CD
- CD3 Complex
- Cell Death
- Cell Transformation, Neoplastic
- Flow Cytometry
- Histocompatibility Antigens Class I
- Humans
- Interferon-gamma
- Interleukin-2