Article
Maturation of murine natural killer precursor cells in the absence of exogenous cytokines requires contact with bone marrow stroma.
Natural immunity - 1 Jan 2000
Tsuji J M, Pollack S B
Abstract excerpt
To test whether differentiation of natural killer (NK) precursor cells in unsupplemented long-term bone marrow culture requires contact with stromal cells, bone marrow cells (BMC) that were depleted of NK 1.1+ and Thy-1+ cells were cultured either directly on established, irradiated bone marrow stroma or in cell culture inserts separated from the stroma by a 0.45-micron microporous membrane. No exogenous...
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