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Article

Activated Tissue-Resident Mesenchymal Stromal Cells Regulate Natural Killer Cell Immune and Tissue-Regenerative Function.

Stem cell reports - 12 Sept 2017

Petri Robert Michael, Hackel Alexander, Hahnel Katrin, Dumitru Claudia Alexandra, Bruderek Kirsten, Flohe Stefanie B, Paschen Annette, Lang Stephan, Brandau Sven

Abstract excerpt

The interaction of mesenchymal stromal cells (MSCs) with natural killer (NK) cells is traditionally thought of as a static inhibitory model, whereby resting MSCs inhibit NK cell effector function. Here, we use a dynamic in vitro system of poly(I:C) stimulation to model the interaction of NK cells and tissue-resident MSCs in the context of infection or tissue injury. The experiments suggest a time-dependent system...

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Identifiers

PMID: 28781075
DOI: 10.1016/j.stemcr.2017.06.020
PMCID: PMC5599186

Genes

MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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