[Oxidative damage of mitochondrial DNA: the result or consequence of enhanced generation of reactive oxygen species].

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Article

[Oxidative damage of mitochondrial DNA: the result or consequence of enhanced generation of reactive oxygen species].

Postepy biochemii - 1 Jan 2010

Płoszaj Tomasz, Robaszkiewicz Agnieszka, Witas Henryk

Abstract excerpt

According to mitochondrial theory of ageing the ageing process results from accumulation of mitochondrial DNA (mtDNA) damage. Close vicinity of mtDNA molecule to the source of reactive oxygen species, electron transport chain, potentiates degradation of nucleic acid chemical components. The most common types of mtDNA damage generated are point mutations as a result of oxidative modifications of purines and...

Topics

Aging
Animals
DNA Damage
DNA Repair
DNA, Mitochondrial
Energy Metabolism
Humans
Ketoglutarate Dehydrogenase Complex
Mutation
Oxidative Stress
Reactive Oxygen Species

Source

Open in PubMed

Identifiers

PMID: 20873108

Provenance

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