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Article

[Oxidative damage of mitochondrial DNA: the result or consequence of enhanced generation of reactive oxygen species].

Postepy biochemii - 1 Jan 2010

Płoszaj Tomasz, Robaszkiewicz Agnieszka, Witas Henryk

Abstract excerpt

According to mitochondrial theory of ageing the ageing process results from accumulation of mitochondrial DNA (mtDNA) damage. Close vicinity of mtDNA molecule to the source of reactive oxygen species, electron transport chain, potentiates degradation of nucleic acid chemical components. The most common types of mtDNA damage generated are point mutations as a result of oxidative modifications of purines and...

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Identifiers

PMID: 20873108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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