Article
The mouse acrodermatitis enteropathica gene Slc39a4 (Zip4) is essential for early development and heterozygosity causes hypersensitivity to zinc deficiency.
Human molecular genetics - 15 Jun 2007
Dufner-Beattie Jodi, Weaver Benjamin P, Geiser Jim, Bilgen Mehmet, Larson Melissa, Xu Wenhao, Andrews Glen K
Abstract excerpt
The human Zip4 gene (Slc39a4) is mutated in the rare recessive genetic disorder of zinc metabolism acrodermatitis enteropathica, but the physiological functions of Zip4 are not well understood. Herein we demonstrate that homozygous Zip4-knockout mouse embryos die during early morphogenesis and heterozygous offspring are significantly underrepresented. At mid-gestation, an array of developmental defects including...
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