Hydrocephalus in the Otx2+/- mutant mouse.

doi:10.1006/exnr.1997.6638

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Article

Hydrocephalus in the Otx2+/- mutant mouse.

Experimental neurology - 1 Nov 1997

Makiyama Y, Shoji S, Mizusawa H

Abstract excerpt

Mice with the Otx2+/- mutation often die during the postneonatal period. Before death these animals, generated from TT2 ES cells and crossed with CBA mice, develop a dome-shaped head, weakness of the limbs, kyphosis, lethargy, drowsiness, and emaciation. Autopsy of these mice revealed eminent dil...

Topics

Abnormalities, Multiple
Animals
Body Weight
Dwarfism
Embryonic and Fetal Development
Female
Genes, Lethal
Genotype
Growth Hormone
Head
Homeodomain Proteins
Hydrocephalus
Male
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Mice, Mutant Strains
Morphogenesis

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