Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hydrocephalus in the Otx2+/- mutant mouse.

Experimental neurology - 1 Nov 1997

Makiyama Y, Shoji S, Mizusawa H

Abstract excerpt

Mice with the Otx2+/- mutation often die during the postneonatal period. Before death these animals, generated from TT2 ES cells and crossed with CBA mice, develop a dome-shaped head, weakness of the limbs, kyphosis, lethargy, drowsiness, and emaciation. Autopsy of these mice revealed eminent dilatation of lateral ventricles and a ballooned cerebrum. Histological analysis shows edematous change of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Abnormalities, Multiple
Share to Genes, Lethal
Share to Genotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Homeodomain Proteins

Share to Mice, Inbred C57BL

Share to Mice, Mutant Strains

Share to Morphogenesis

Source

Identifiers

PMID: 9398463
DOI: 10.1006/exnr.1997.6638

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hydrocephalus in the Otx2+/- mutant mouse.PMID 9398463Read ↗

OTX2 Syndromes.Semantic proximity Read ↗

Congenital hydrocephalus in hy3 mice is caused by a frameshift mutation in Hydin, a large novel geneSemantic proximity Read ↗

Genetic modifiers of otocephalic phenotypes in Otx2 heterozygous mutant mice.Semantic proximity Read ↗

OTX2 microphthalmia syndrome: four novel mutations and delineation of a phenotype.Semantic proximity Read ↗

OTX2 mutations contribute to the otocephaly-dysgnathia complexSemantic proximity Read ↗

Disruption of the mouse Jhy gene causes abnormal ciliary microtubule patterning and juvenile hydrocephalus.Semantic proximity Read ↗

Hydrocephalus in Connection to Genetic Mutation in Cranial Neural Crest Cells.Semantic proximity Read ↗

Deletion of OTX2 in neural ectoderm delays anterior pituitary development.Semantic proximity Read ↗

The phenotypic spectrum associated with OTX2 mutations in humans.Semantic proximity Read ↗

Mouse Otx2 functions in the formation and patterning of rostral head.Semantic proximity Read ↗

Heterozygous FOXJ1 Mutations Cause Incomplete Ependymal Cell Differentiation and Communicating Hydrocephalus.Semantic proximity Read ↗

Mouse H6 Homeobox 1 (Hmx1) mutations cause cranial abnormalities and reduced body mass.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.