Article
Somatic cell mutation frequency at the HPRT, T-cell antigen receptor and glycophorin A loci in Cockayne syndrome.
Mutation research - 1 Jul 1995
Lin Y W, Kubota M, Hirota H, Furusho K, Tomiwa K, Ochi J, Kasahara Y, Sasaki H, Ohta S
Abstract excerpt
Skin fibroblasts of patients with Cockayne syndrome (CS) are hypersensitive to the lethal or mutagenic effect of ultraviolet light, which may cause genetic instability. Up to now, however, no systematic study of in vivo somatic cell mutation in CS cells has been reported. This article describes o...
Topics
- Adolescent
- B-Lymphocytes
- Cell Line, Transformed
- Child
- Child, Preschool
- Cockayne Syndrome
- DNA Repair
- Female
- Gene Frequency
- Glycophorins
- Humans
- Hypoxanthine Phosphoribosyltransferase