Article
The tyrosine-6 hydroxyl of gamma delta resolvase is not required for the DNA cleavage and rejoining reactions.
Molecular microbiology - 1 Mar 1995
Leschziner A E, Boocock M R, Grindley N D
Abstract excerpt
Site-specific recombinases of the resolvase and DNA invertase family all contain a tyrosine residue close to the N-terminus, and four residues away from a serine that has been implicated in catalysis of DNA strand breakage and reunion. To examine the role of this tyrosine in recombination, we hav...
Topics
- Amino Acid Sequence
- DNA
- DNA Nucleotidyltransferases
- DNA Topoisomerases, Type I
- DNA-Binding Proteins
- Integrases
- Molecular Sequence Data
- Mutagenesis
- Nucleotidyltransferases
- Phenotype
- Point Mutation
- Recombinases
- Recombination, Genetic
- Sequence Homology, Amino Acid
- Transposases
- Tyrosine