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Article

Beneficial effects of insulin-like growth factor-I on wobbler mouse motoneuron disease.

Journal of the neurological sciences - 1 May 1995

Hantaï D, Akaaboune M, Lagord C, Murawsky M, Houenou L J, Festoff B W, Vaught J L, Rieger F, Blondet B

Abstract excerpt

Recombinant human insulin-like growth factor-I (IGF-I) is being considered as a possible therapeutic agent for the treatment of motoneuron diseases like amyotrophic lateral sclerosis. The neurological mutant mouse wobbler, carries an autosomal recessive gene (wr) and has been characterized as a model of lower motoneuron disorders with associated muscle atrophy, denervation and reinnervation. The purpose of the...

Topics

Animals
Body Weight
Choline O-Acetyltransferase
Hand Strength
Humans
Insulin-Like Growth Factor I
Mice
Mice, Inbred C57BL
Mice, Neurologic Mutants
Motor Neuron Disease
Muscles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neuromuscular Agents

Phenotype

Recombinant Proteins

Spinal Cord

Source

Identifiers

PMID: 7595602
DOI: 10.1016/0022-510x(95)00081-c

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7595602-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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