Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Beneficial effects of insulin-like growth factor-I on wobbler mouse motoneuron disease.

Journal of the neurological sciences - 1 May 1995

Hantaï D, Akaaboune M, Lagord C, Murawsky M, Houenou L J, Festoff B W, Vaught J L, Rieger F, Blondet B

Abstract excerpt

Recombinant human insulin-like growth factor-I (IGF-I) is being considered as a possible therapeutic agent for the treatment of motoneuron diseases like amyotrophic lateral sclerosis. The neurological mutant mouse wobbler, carries an autosomal recessive gene (wr) and has been characterized as a model of lower motoneuron disorders with associated muscle atrophy, denervation and reinnervation. The purpose of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Weight
Share to Insulin-Like Growth Factor I

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Mice, Neurologic Mutants

Share to Muscles

Share to Phenotype

Share to Recombinant Proteins

Source

Identifiers

PMID: 7595602
DOI: 10.1016/0022-510x(95)00081-c

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Beneficial effects of insulin-like growth factor-I on wobbler mouse motoneuron disease.PMID 7595602Read ↗

Therapeutic potential of PEGylated insulin-like growth factor I for skeletal muscle disease evaluated in two murine models of muscular dystrophy.Semantic proximity Read ↗

Skeletal muscle-specific overexpression of IGFBP-2 promotes a slower muscle phenotype in healthy but not dystrophic mdx mice and does not affect the dystrophic pathology.Semantic proximity Read ↗

IGF-1R Reduction Triggers Neuroprotective Signaling Pathways in Spinal Muscular Atrophy MiceSemantic proximity Read ↗

The lack of effect of specific overexpression of IGF-1 in the central nervous system or skeletal muscle on pathophysiology in the G93A SOD-1 mouse model of ALS.Semantic proximity Read ↗

Targeted Expression of IGF‐1 Transgene to Skeletal Muscle Accelerates Muscle and Motor Neuron RegenerationSemantic proximity Read ↗

Systemic Administration of a Recombinant AAV1 Vector Encoding IGF-1 Improves Disease Manifestations in SMA MiceSemantic proximity Read ↗

Mutant mouse models of insulin-like growth factor actions in the central nervous system.Semantic proximity Read ↗

Transforming growth factor alpha expression as a response of murine motor neurons to axonal injury and mutation-induced degeneration.Semantic proximity Read ↗

Overexpression of IGF-I in skeletal muscle of transgenic mice does not prevent unloading-induced atrophySemantic proximity Read ↗

Genetic transfer of the wobbler gene to a C57BL/6J x NZB hybrid stock: natural history of the motor neuron disease and response to CNTF and BDNF cotreatment.Semantic proximity Read ↗

Bcl-2 sensitivity differentiates two pathways for motoneuronal death in the wobbler mutant mouse.Semantic proximity Read ↗

A novel behavioral method to detect motoneuron disease in Wobbler mice aged three to seven days old.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.