Skeletal muscle-specific overexpression of IGFBP-2 promotes a slower muscle phenotype in healthy but not dystrophic mdx mice and does not affect the dystrophic pathology.

doi:10.1016/j.ghir.2016.07.002

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Article

Skeletal muscle-specific overexpression of IGFBP-2 promotes a slower muscle phenotype in healthy but not dystrophic mdx mice and does not affect the dystrophic pathology.

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society - 1 Jan 2000

Swiderski Kristy, Martins Karen Janet Bernice, Chee Annabel, Trieu Jennifer, Naim Timur, Gehrig Stefan Martin, Baum Dale Michael, Brenmoehl Julia, Chau Luong, Koopman René, Gregorevic Paul, Metzger Friedrich, Hoeflich Andreas, Lynch Gordon Stuart

Abstract excerpt

OBJECTIVE: The insulin-like growth factor binding proteins (IGFBPs) are thought to modulate cell size and homeostasis via IGF-I-dependent and -independent pathways. There is a considerable dearth of information regarding the function of IGFBPs in skeletal muscle, particularly their role in the pathophysiology of Duchenne muscular dystrophy (DMD). In this study we tested the hypothesis that intramuscular IGFBP-2...

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PMID: 27544574
DOI: 10.1016/j.ghir.2016.07.002

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