Bcl-2 sensitivity differentiates two pathways for motoneuronal death in the wobbler mutant mouse.

Article

Bcl-2 sensitivity differentiates two pathways for motoneuronal death in the wobbler mutant mouse.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Oct 1996

Coulpier M, Junier M P, Peschanski M, Dreyfus P A

Abstract excerpt

The molecular events leading to motoneuronal death are still poorly understood. In mammals, the bcl-2 proto-oncogene, which encodes a membrane-associated protein, has been shown to suppress both developmental motoneuronal death and experimental axotomy-induced motoneuronal death. We assessed a po...

Topics

Animals
Cell Death
Gene Expression
Humans
Mice
Mice, Neurologic Mutants
Motor Neurons
Phenotype
Proto-Oncogene Mas
Proto-Oncogene Proteins c-bcl-2
Transgenes

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