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Article

Regulation of cytoplasmic dynein function in vivo by the Drosophila Glued complex.

The Journal of cell biology - 1 Oct 1995

McGrail M, Gepner J, Silvanovich A, Ludmann S, Serr M, Hays T S

Abstract excerpt

The Drosophila Glued gene product shares sequence homology with the p150 component of vertebrate dynactin. Dynactin is a multiprotein complex that stimulates cytoplasmic dynein-mediated vesicle motility in vitro. In this report, we present biochemical, cytological, and genetic evidence that demonstrates a functional similarity between the Drosophila Glued complex and vertebrate dynactin. We show that, similar to...

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Identifiers

PMID: 7593168
DOI: 10.1083/jcb.131.2.411
PMCID: PMC2199972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of cytoplasmic dynein function in vivo by the Drosophila Glued complex.PMID 7593168Read ↗

A molecular genetic analysis of the interaction between the cytoplasmic dynein intermediate chain and the glued (dynactin) complex.Semantic proximity Read ↗

A modifier screen in the Drosophila eye reveals that aPKC interacts with Glued during central synapse formation.Semantic proximity Read ↗

The Saccharomyces cerevisiae homolog of p24 is essential for maintaining the association of p150Glued with the dynactin complex.Semantic proximity Read ↗

The gene for the intermediate chain subunit of cytoplasmic dynein is essential in Drosophila.Semantic proximity Read ↗

Normal dynactin complex function during synapse growth in Drosophila requires membrane binding by Arfaptin.Semantic proximity Read ↗

Dynactin-membrane interaction is regulated by the C-terminal domains of p150(Glued).Semantic proximity Read ↗

Dynein-dynactin segregate meiotic chromosomes in <i>C. elegans</i> spermatocytesSemantic proximity Read ↗

Genetic analysis of mutations at the Glued locus and interacting loci in Drosophila melanogaster.Semantic proximity Read ↗

The p150(Glued) CAP-Gly domain regulates initiation of retrograde transport at synaptic termini.Semantic proximity Read ↗

Dynactin subunit p150(Glued) is a neuron-specific anti-catastrophe factor.Semantic proximity Read ↗

Dynein and Star interact in EGFR signaling and ligand trafficking.Semantic proximity Read ↗

Cytoplasmic dynein, the dynactin complex, and kinesin are interdependent and essential for fast axonal transport.Semantic proximity Read ↗

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