Article
A human pancreatic secretory trypsin inhibitor presenting a hypervariable highly constrained epitope via monovalent phagemid display.
Gene - 27 Oct 1995
Röttgen P, Collins J
Abstract excerpt
Hypervariable gene banks displaying ligands which can be used for affinity optimisation are valuable resources for examining shape space. They have added value if the ligand is small, if there is extensive information on its tertiary structure and if the variable region is highly constrained. The...
Topics
- Amino Acid Sequence
- Animals
- Bacteriophages
- Base Sequence
- DNA Primers
- Epitopes
- Gene Library
- Genes, Synthetic
- Genetic Variation
- Hominidae
- Humans
- Molecular Sequence Data
- Mutagenesis, Insertional
- Plasmids
- Polymerase Chain Reaction
- Recombinant Proteins
- Restriction Mapping
- Trypsin Inhibitor, Kazal Pancreatic