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Article

Bmp7 drives proximal tubule expansion and determines nephron number in the developing kidney

15 Jul 2022

Abstract excerpt

The mammalian kidney is composed of thousands of nephrons that are formed through reiterative induction of a mesenchymal-to-epithelial transformation by a population of nephron progenitor cells. The number of nephrons in human kidneys ranges from several hundred thousand to nearly a million, and low nephron number has been implicated as a risk factor for kidney disease as an adult. Bmp7 is among a small number of...

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PMID: 35877077
DOI: 10.1242/dev.200773

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