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Article

Haplotype analysis of CYP11B2.

Endocrine research - 1 Jan 2000

White P C, Slutsker L

Abstract excerpt

Polymorphisms affecting the synthesis of aldosterone or its regulation may have effects on blood pressure. For example, an autosomal dominant form of human hypertension, glucocorticoid suppressible hyperaldosteronism, is caused by recombination between the genes for aldosterone synthase (CYP11B2) and steroid 11 beta-hydroxylase (CYP11B1), creating a chimeric gene in which the CYP11B1 promoter and CYP11B2-specific...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 7588407
DOI: 10.3109/07435809509030459

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Haplotype analysis of CYP11B2.PMID 7588407Read ↗

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The impact of polymorphisms in the gene encoding aldosterone synthase (CYP11B2) on steroid synthesis and blood pressure regulation.Semantic proximity Read ↗

Genetic recombination as a cause of inherited disorders of aldosterone and cortisol biosynthesis and a contributor to genetic variation in blood pressure.Semantic proximity Read ↗

Structural analysis and evaluation of the aldosterone synthase gene in hypertension.Semantic proximity Read ↗

CYP11B2 gene polymorphisms in idiopathic hyperaldosteronism.Semantic proximity Read ↗

Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion.Semantic proximity Read ↗

Polymorphic variation in the 11beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency.Semantic proximity Read ↗

Deletion Hybrid Genes, due to Unequal Crossing Over betweenCYP11B1(11β-Hydroxylase) andCYP11B2(Aldosterone Synthase) Cause Steroid 11β-Hydroxylase Deficiency and Congenital Adrenal Hyperplasia1Semantic proximity Read ↗

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Genetic analysis of aldosterone synthase in patients with idiopathic hyperaldosteronism.Semantic proximity Read ↗

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