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Article

Alterations in DNA Repair Efficiency are Involved in the Radioresistance of Esophageal Adenocarcinoma

4 Oct 2010

Abstract excerpt

To study radioresistance in esophageal adenocarcinoma, we generated an isogenic cell line model by exposing OE33 esophageal adenocarcinoma cells to clinically relevant fractionated doses of radiation (cumulative dose 50 Gy). A clonogenic assay confirmed enhanced survival of the radioresistant OE33 subline (OE33 R). To our knowledge, we are the first to generate an isogenic model of radioresistance in esophageal...

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PMID: 21128793
DOI: 10.1667/rr2295.1

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