Article
Gridlock, a localized heritable vascular patterning defect in the zebrafish.
Nature medicine - 1 Nov 1995
Weinstein B M, Stemple D L, Driever W, Fishman M C
Abstract excerpt
We are using the zebrafish, Danio rerio, to identify genes that generate and pattern the vertebrate vasculature. We have isolated a recessive mutation, gridlockm145 (grlm145) in which blood flow to the tail is impeded by a localized vascular defect. Using a novel microangiographic method, we show that the blockade is in the anterior trunk, where the paired lateral dorsal aortae normally merge to form the single...
Topics
- Angiography
- Animals
- Aorta
- Aorta, Thoracic
- Aortic Coarctation
- Blood Circulation
- Genes, Recessive
- Humans
- Mutation
- Zebrafish