Article
Loss of function of parathyroid hormone receptor 1 induces Notch-dependent aortic defects during zebrafish vascular development.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2013
Gray Caroline, Bratt David, Lees Julie, daCosta Marc, Plant Karen, Watson Oliver J, Solaymani-Kohal Sara, Tazzyman Simon, Serbanovic-Canic Jovana, Crossman David C, Keavney Bernard D, Haase Andrea, McMahon Kathryn, Gering Martin, Roehl Henry, Evans Paul C, Chico Timothy J A
Abstract excerpt
OBJECTIVE: Coarctation of the aorta is rarely associated with known gene defects. Blomstrand chondrodysplasia, caused by mutations in the parathyroid hormone receptor 1 (PTHR1) is associated with coarctation of the aorta in some cases, although it is unclear whether PTHR1 deficiency causes coarctation of the aorta directly. The zebrafish allows the study of vascular development using approaches not possible in...
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