Article
Cyclosporin A promotes nuclear transfer of a cytoplasmic progesterone receptor mutant.
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie - 1 Aug 1995
Jung-Testas I, Lebeau M C, Catelli M G, Baulieu E E
Abstract excerpt
The effects of cyclosporin A (CsA), FK506 and rapamycin (Rapa) on the intracellular localization of a mutated rabbit progesterone receptor (PR) which lacks the main constitutive nuclear localization signal (NLS) (delta 638-642) and is cytoplasmic in the absence of progesterone (Prog), were assayed by indirect immunofluorescence in Lcl3 cells, a mouse L-cell line stably expressing this mutant. CsA alone, at 5-10...
Topics
- Animals
- Cells, Cultured
- Cyclosporine
- Cytoplasm
- Fibroblasts
- Immunosuppressive Agents
- Mice
- Mifepristone
- Mutation
- Polyenes
- Rabbits
- Receptors, Progesterone