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Article

Human cytochrome p450 family 4 enzymes: function, genetic variation and regulation.

Drug metabolism reviews - 1 Jan 2007

Hsu Mei-Hui, Savas Uzen, Griffin Keith J, Johnson Eric F

Abstract excerpt

The microsomal cytochrome P450 (CYP) family 4 monooxygenases are the major fatty acid omega-hydroxylases. These enzymes remove excess free fatty acids to prevent lipotoxicity, catabolize leukotrienes and prostanoids, and also produce bioactive metabolites from arachidonic acid omega-hydroxylation. In addition to endogenous substrates, recent evidence indicates that CYP4 monooxygenases can also metabolize...

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Identifiers

PMID: 17786636
DOI: 10.1080/03602530701468573

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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