Article
The expression pattern of erythrocyte/megakaryocyte-related transcription factors GATA-1 and the stem cell leukemia gene correlates with hematopoietic differentiation and is associated with outcome of acute myeloid leukemia.
Blood - 15 Oct 1995
Shimamoto T, Ohyashiki K, Ohyashiki J H, Kawakubo K, Fujimura T, Iwama H, Nakazawa S, Toyama K
Abstract excerpt
To understand the clinical implications of transcription factors and their biologic roles during cellular differentiation in the hematopoietic system, we examined the expression of GATA-1, GATA-2, and stem cell leukemia (SCL) gene in human leukemia cell lines and various leukemia patients using t...
Topics
- Acute Disease
- Adult
- Base Sequence
- Basic Helix-Loop-Helix Transcription Factors
- Blast Crisis
- Cell Differentiation
- DNA-Binding Proteins
- Erythroid-Specific DNA-Binding Factors
- GATA1 Transcription Factor
- GATA2 Transcription Factor
- Gene Expression Regulation, Leukemic
- Hematopoietic Stem Cells