Article
T-cell receptor polymorphisms in Tlingit Indians with rheumatoid arthritis.
Autoimmunity - 1 Jan 1994
Charmley P, Nelson J L, Hansen J A, Branchaud A, Barrington R A, Templin D, Boyer G, Lanier A P, Concannon P
Abstract excerpt
Rheumatoid arthritis (RA) develops as a result of the interaction of both genetic and environmental factors. Among the genes in humans that have been suggested as candidate susceptibility genes in RA are those encoding the T cell receptor for antigen (TCR). A high prevalence and early age of onset of RA has previously been reported in Alaskan Tlingit Indians. In this study, the frequency of seven different...
Topics
- Alleles
- Arthritis, Rheumatoid
- Humans
- Indians, North American
- Polymorphism, Restriction Fragment Length
- Receptors, Antigen, T-Cell, alpha-beta
- White People