Article
The C-terminal region, Arg201-Gln209, of glutathione S-transferase P contributes to stability of the active-site conformation.
Biochimica et biophysica acta - 25 Oct 1995
Nishihira J, Hibiya Y, Sakai M, Nishi S, Kumazaki T, Ohki S, Sakamoto W
Abstract excerpt
The C-terminal region of rat glutathione S-transferase P (GST-P) was deleted by either carboxypeptidase (CPase) A and B or site-specific truncation to evaluate the role of the region in the catalytic mechanism. The C-terminal sequence from the 201st to 209th amino-acid residues is Arg-Pro-Ile-Asn...
Topics
- Amino Acid Sequence
- Animals
- Arginine
- Binding Sites
- Carboxypeptidases
- Catalysis
- Enzyme Stability
- Glutathione Transferase
- Glycine
- Magnetic Resonance Spectroscopy
- Molecular Sequence Data
- Mutation