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Article

Localization of the C-terminus of rat glutathione S-transferase A1-1: crystal structure of mutants W21F and W21F/F220Y.

Proteins - 1 Feb 2001

Adman E T, Le Trong I, Stenkamp R E, Nieslanik B S, Dietze E C, Tai G, Ibarra C, Atkins W M

Abstract excerpt

Twelve C-terminal residues of human glutathione S-transferase A1-1 form a helix in the presence of glutathione-conjugate, or substrate alone, and partly cover the active site. According to X-ray structures, the helix is disordered in the absence of glutathione, but it is not known if it is helical and delocalized, or in a random-coil conformation. Mutation to a tyrosine of residue 220 within this helix was...

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PMID: 11119643
DOI: 10.1002/1097-0134(20010201)42:2<192::aid-prot60>3.0.co;2-#

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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