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Article

Activating mutations in human c-Ha-ras-1 protooncogene induced by stereoisomeric fjord-region benzo[c]chrysene diol-epoxides.

Molecular carcinogenesis - 1 Nov 1995

Du M Q, Seidel A, Phillips D H

Abstract excerpt

The mutagenicity of fjord-region benzo[c]chrysene diol-epoxide (BcCDE) stereoisomers((+) anti-BcCDE, (-)anti-BcCDE, (+)syn-BcCDE, and (-)syn-BcCDE) was studied in a forward-mutation system. pEC plasmid containing the human c-Ha-ras-1 proto-oncogene was reacted in vitro with each optically active...

Topics

3T3 Cells
Animals
Base Sequence
Chrysenes
Gene Expression Regulation
Genes, ras
Humans
Mice
Molecular Sequence Data
Mutagenicity Tests
Mutagens
Mutation
Nucleic Acid Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotide Probes

Point Mutation

Polymerase Chain Reaction

Proto-Oncogene Mas

Stereoisomerism

Source

Identifiers

PMID: 7576108
DOI: 10.1002/mc.2940140305

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7576108-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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