Article
The influenza virus NS1 protein forms multimers in vitro and in vivo.
Virology - 1 Oct 1995
Nemeroff M E, Qian X Y, Krug R M
Abstract excerpt
The NS1 protein of the influenza A virus inhibits both the nuclear export of mRNA and pre-mRNA splicing. Two functional domains, an RNA-binding domain and an effector domain, have been identified in this protein. Here we demonstrate that the NS1 protein exists as a dimer in vitro both in the absence of its RNA target and when it is bound to a specific RNA target, U6 snRNA. This indicates that it is most likely...
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