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Article

Dimer interface of the effector domain of non-structural protein 1 from influenza A virus: an interface with multiple functions.

The Journal of biological chemistry - 22 Jul 2011

Aramini James M, Ma Li-Chung, Zhou Ligang, Schauder Curtis M, Hamilton Keith, Amer Brendan R, Mack Timothy R, Lee Hsiau-Wei, Ciccosanti Colleen T, Zhao Li, Xiao Rong, Krug Robert M, Montelione Gaetano T

Abstract excerpt

Non-structural protein 1 from influenza A virus, NS1A, is a key multifunctional virulence factor composed of two domains: an N-terminal double-stranded RNA (dsRNA)-binding domain and a C-terminal effector domain (ED). Isolated RNA-binding and effector domains of NS1A both exist as homodimers in solution. Despite recent crystal structures of isolated ED and full-length NS1A proteins from different influenza virus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21622573
DOI: 10.1074/jbc.M111.248765
PMCID: PMC3138300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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