Article
A transient homotypic interaction model for the influenza A virus NS1 protein effector domain.
PloS one - 28 Mar 2011
Kerry Philip S, Ayllon Juan, Taylor Margaret A, Hass Claudia, Lewis Andrew, García-Sastre Adolfo, Randall Richard E, Hale Benjamin G, Russell Rupert J
Abstract excerpt
Influenza A virus NS1 protein is a multifunctional virulence factor consisting of an RNA binding domain (RBD), a short linker, an effector domain (ED), and a C-terminal 'tail'. Although poorly understood, NS1 multimerization may autoregulate its actions. While RBD dimerization seems functionally conserved, two possible apo ED dimers have been proposed (helix-helix and strand-strand). Here, we analyze all...
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