Article
Alzheimer's disease: a model from the quantitative study of a large kindred.
Journal of geriatric psychiatry and neurology - 1 Jan 2000
Bruni A C, Montesi M P, Salmon D, Gei G, Perre J, el Hachimi K H, Foncin J F
Abstract excerpt
In an Italian kindred (family N), early onset Alzheimer's disease has been transmitted in a Mendelian autosomal fashion since the early 18th century. The age at death of affected members of the family varies widely, and was taken as an index of the age of expression, a measure of phenotypic variability. Either a gamma or a log-normal algorithm provides the best fit for the age at death distribution. Subsets of...
Topics
- Adult
- Age Factors
- Aged
- Alzheimer Disease
- Atrophy
- Brain
- Gene Expression Regulation
- Humans
- Male
- Middle Aged
- Models, Statistical
- Phenotype