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Article

The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome.

The New England journal of medicine - 2 Nov 1995

Bosma P J, Chowdhury J R, Bakker C, Gantla S, de Boer A, Oostra B A, Lindhout D, Tytgat G N, Jansen P L, Oude Elferink R P

Abstract excerpt

BACKGROUND: People with Gilbert's syndrome have mild, chronic unconjugated hyperbilirubinemia in the absence of liver disease or overt hemolysis. Hepatic glucuronidating activity, essential for efficient biliary excretion of bilirubin, is reduced to about 30 percent of normal. METHODS: We sequenced the coding and promoter regions of the gene for bilirubin UDP-glucuronosyltransferase 1 (bilirubin/uridine...

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Identifiers

PMID: 7565971
DOI: 10.1056/NEJM199511023331802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome.PMID 7565971Read ↗

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