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Article

[A study of polymorphism in UDP-glucuronosyltransferase 1 (UGT-1A1) promoter gene in Korean patients with Gilbert's syndrome].

Taehan Kan Hakhoe chi = The Korean journal of hepatology - 1 Jun 2002

Kim Yoon Hong, Yeon Jong Eun, Jung Gil Man, Kim Hyo Jung, Kim Jae Seon, Byun Kwan Soo, Bak Young Tae, Lee Chang Hong

Abstract excerpt

BACKGROUND/AIMS: Hepatic glucuronidating activity, essential for efficient biliary excretion of bilirubin, is reduced to about 30 percent of normal in patients with Gilbert's syndrome. Patients with Gilbert's syndrome have an additional TA insertion in the A(TA)TAA of UDP-glucuronosyltransferase 1 (UGT-1A1) promoter gene. This results in reduced frequency and accuracy of transcription initiation and enzyme...

Topics

Adult
Female
Gilbert Disease
Glucuronosyltransferase
Humans
Korea
Male
Mutation
Polymorphism, Genetic
Promoter Regions, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12499798

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