Article
Molecular population genetic analysis of the streptokinase gene of Streptococcus pyogenes: mosaic alleles generated by recombination.
Molecular microbiology - 1 May 1995
Kapur V, Kanjilal S, Hamrick M R, Li L L, Whittam T S, Sawyer S A, Musser J M
Abstract excerpt
To understand the mechanisms governing molecular evolution of the streptokinase gene (skn), a 384 bp DNA fragment encoding two variable regions of the molecule was characterized in 47 isolates of Streptococcus pyogenes. The results reveal that alleles of the streptokinase gene have a mosaic structure, and provide strong evidence for intragenic recombination. Moreover, organisms that are well differentiated in...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Chromosomes, Bacterial
- Genes, Bacterial
- Molecular Sequence Data
- Phylogeny
- Recombination, Genetic
- Sequence Alignment
- Sequence Homology, Amino Acid