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Article

Synonymous substitution rates in enterobacteria.

Genetics - 1 Aug 1995

Eyre-Walker A, Bulmer M

Abstract excerpt

It has been shown previously that the synonymous substitution rate between Escherichia coli and Salmonella typhimurium is lower in highly than in weakly expressed genes, and it has been suggested that this is due to stronger selection for translational efficiency in highly expressed genes as reflected in their greater codon usage bias. This hypothesis is tested here by comparing the substitution rate in codon...

Topics

Codon
Enterobacteriaceae
Escherichia coli
Evolution, Molecular
Gene Frequency
Models, Genetic
Mutation
Protein Biosynthesis
Salmonella typhimurium
Selection, Genetic
Sequence Alignment

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Identifiers

PMID: 7498779
DOI: 10.1093/genetics/140.4.1407
PMCID: PMC1206703

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7498779-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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