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Article

Activation of Rac1-dependent redox signaling is critically involved in staurosporine-induced neurite outgrowth in PC12 cells.

Free radical research - 1 Feb 2013

Kim Du Sik, An Jeong Mi, Lee Han Gil, Seo Su Ryeon, Kim Seon Sook, Kim Ju Yeon, Kang Jeong Wan, Bae Yun Soo, Seo Jeong Taeg

Abstract excerpt

Staurosporine, a non-specific protein kinase inhibitor, has been shown to induce neurite outgrowth in PC12 cells, but the mechanism by which staurosporine induces neurite outgrowth is still obscure. In the present study, we investigated whether the activation of Rac1 was responsible for the neurite outgrowth triggered by staurosporine. Staurosporine caused rapid neurite outgrowth independent of the ERK signaling...

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Identifiers

PMID: 23153365
DOI: 10.3109/10715762.2012.748193

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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