Phorbol esters and PKC signaling regulate proliferation, vimentin cytoskeleton assembly and glutamine synthetase activity of chick embryo cerebrum astrocytes in culture.

doi:10.1016/0165-3806(95)00046-g

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Article

Phorbol esters and PKC signaling regulate proliferation, vimentin cytoskeleton assembly and glutamine synthetase activity of chick embryo cerebrum astrocytes in culture.

Brain research. Developmental brain research - 27 Jun 1995

Mangoura D, Sogos V, Dawson G

Abstract excerpt

We have recently shown that expression of specific protein kinase C (PKC) isoforms correlates with cell fate in neural chicken embryo cells. Therefore we investigated the effects of PKC activation by phorbol esters on acquisition of the astrocytic phenotype, using cultured embryonic cortical astrocytes, derived from 15-day-old chick embryos (E15CH), as a model. Short term treatment with the phorbol ester...

Topics

Animals
Astrocytes
Biomarkers
Calcium
Carcinogens
Cell Division
Cell Size
Cells, Cultured
Cerebral Cortex
Chick Embryo
Cytoskeleton

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glutamate-Ammonia Ligase

Isoenzymes

Phenotype

Phorbol Esters

Phosphorylation

Protein Kinase C

Protein Kinase C beta

Source

Open in PubMed

Identifiers

PMID: 7554227
DOI: 10.1016/0165-3806(95)00046-g

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7554227-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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