Article
Mutated yeast heat shock transcription factor exhibits elevated basal transcriptional activation and confers metal resistance.
The Journal of biological chemistry - 20 Oct 1995
Sewell A K, Yokoya F, Yu W, Miyagawa T, Murayama T, Winge D R
Abstract excerpt
Cadmium-resistant Saccharomyces cerevisiae strain 301N exhibits high basal as well as cadmium-induced expression of the CUP1 metallothionein gene. Since regulation of CUP1 is usually restricted to copper ions, our goal was to identify the factor responsible for the high metallothionein levels in strain 301N. The gene responsible for the observed phenotype is a spontaneously mutated heat shock transcription factor...
Topics
- Base Sequence
- Cadmium
- Cloning, Molecular
- DNA
- DNA-Binding Proteins
- Heat-Shock Proteins
- Hot Temperature
- Metallothionein
- Molecular Sequence Data
- Mutation
- Saccharomyces cerevisiae