Article
Role of heat shock transcription factor in yeast metallothionein gene expression.
Molecular and cellular biology - 1 Jul 1991
Yang W M, Gahl W, Hamer D
Abstract excerpt
The induction of Saccharomyces cerevisiae metallothionein gene transcription by Cu and Ag is mediated by the ACE1 transcription factor. In an effort to detect additional stimuli and factors that regulate metallothionein gene transcription, we isolated a Cu-resistant suppressor mutant of an ACE1 deletion strain. Even in the absence of metals, the suppressor mutant exhibited high basal levels of metallothionein...
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