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Article

Non-heat shock responsive roles of HSF1 in Candida albicans are essential under iron deprivation and drug defense.

Biochimica et biophysica acta. Molecular cell research - 1 Feb 2017

Nair Remya, Shariq Mohd, Dhamgaye Sanjiveeni, Mukhopadhyay Chinmay K, Shaikh Shamim, Prasad Rajendra

Abstract excerpt

Recently, we have reported that the conditional mutant of the heat shock factor-1 (HSF1) in Candida albicans displays enhanced susceptibility not only towards a plant alkaloid, berberine, but also to diverse antifungal drugs. The present study attempts to identify additional phenotypes highlighting the non-heat shock responsive roles of HSF1 that could be correlated with the enhanced drug susceptibility. We...

Topics

Candida albicans
Cell Wall
Drug Resistance, Fungal
Heat-Shock Proteins
Homeostasis
Iron
Mitochondria
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 27889440
DOI: 10.1016/j.bbamcr.2016.11.021

Genes

HSF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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