Article
Variants of tissue-type plasminogen activator with substantially enhanced response and selectivity toward fibrin co-factors.
The Journal of biological chemistry - 6 Oct 1995
Strandberg L, Madison E L
Abstract excerpt
Unlike most proteases, tissue-type plasminogen activator (t-PA) is not synthesized as an inactive precursor or zymogen. Instead, the single-chain "proenzyme" form of t-PA possesses very significant catalytic activity. Recent investigations of the molecular basis of the unusually high enzymatic ac...
Topics
- Animals
- Aspartic Acid
- Base Sequence
- Binding Sites
- DNA Primers
- Fibrin
- Genetic Variation
- Kinetics
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Plasminogen
- Plasminogen Activator Inhibitor 1
- Protein Conformation
- Substrate Specificity
- Tissue Plasminogen Activator