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Article

Modification of penicillin-binding proteins of penicillin-resistant mutants of different species of enterococci.

The Journal of antimicrobial chemotherapy - 1 Nov 1990

al-Obeid S, Gutmann L, Williamson R

Abstract excerpt

Mutants resistant to penicillin G were selected in a stepwise manner from nine different species of enterococci. Mutants with the highest level of resistance showed cross-resistance to all beta-lactams tested. For eight of the nine species, resistance correlated with increased production of a low molecular weight penicillin-binding protein (PBP). Two of these species produced a new PBP of low molecular weight,...

Topics

Bacterial Proteins
Carrier Proteins
Hexosyltransferases
Microbial Sensitivity Tests
Muramoylpentapeptide Carboxypeptidase
Mutation
Penicillin Resistance
Penicillin-Binding Proteins
Peptidyl Transferases
Species Specificity

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Streptococcus

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Identifiers

PMID: 2079445
DOI: 10.1093/jac/26.5.613

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2079445-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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