Article
Modification of penicillin-binding proteins of penicillin-resistant mutants of different species of enterococci.
The Journal of antimicrobial chemotherapy - 1 Nov 1990
al-Obeid S, Gutmann L, Williamson R
Abstract excerpt
Mutants resistant to penicillin G were selected in a stepwise manner from nine different species of enterococci. Mutants with the highest level of resistance showed cross-resistance to all beta-lactams tested. For eight of the nine species, resistance correlated with increased production of a low molecular weight penicillin-binding protein (PBP). Two of these species produced a new PBP of low molecular weight,...
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