Article
Direct analysis for familial adenomatous polyposis mutations.
Molecular biotechnology - 1 Feb 2002
Powell Steven M
Abstract excerpt
The spectrum of disease causing mutations is immense. It just so happens that the overwhelming majority of genetic alterations in the APC gene with leads to adenomatous polyposis coli generate truncated gene products. This observation lead to the development of the in vitro synthesis protein assay (protein truncation test) which is a sensitive method to detect these truncated gene products from patient samples....
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