Article
Potentiation of 2,6-dinitrotoluene genotoxicity in Fischer 344 rats by pretreatment with coal tar creosote.
Journal of toxicology and environmental health - 1 Mar 1995
Chadwick R W, George S E, Kohan M J, Williams R W, Allison J C, Talley D L, Hayes Y O, Chang J
Abstract excerpt
Pretreatment of male Fischer 344 rats for 5 wk with coal tar creosote, a coal distillation product that is widely used as a wood preservative, potentiated the excretion of urinary mutagens in 2,6-dinitrotoluene (DNT) treated rats. Creosote increased the bioactivation of DNT to significantly greater levels of urinary genotoxic metabolites and/or formed DNA adducts in the liver. A significant increase in the...
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