Potentiation of 2,6-dinitrotoluene genotoxicity in Fischer 344 rats by pretreatment with coal tar creosote.

doi:10.1080/15287399509531962

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Article

Potentiation of 2,6-dinitrotoluene genotoxicity in Fischer 344 rats by pretreatment with coal tar creosote.

Journal of toxicology and environmental health - 1 Mar 1995

Chadwick R W, George S E, Kohan M J, Williams R W, Allison J C, Talley D L, Hayes Y O, Chang J

Abstract excerpt

Pretreatment of male Fischer 344 rats for 5 wk with coal tar creosote, a coal distillation product that is widely used as a wood preservative, potentiated the excretion of urinary mutagens in 2,6-dinitrotoluene (DNT) treated rats. Creosote increased the bioactivation of DNT to significantly great...

Topics

Analysis of Variance
Animals
Bacteria, Aerobic
Bacteria, Anaerobic
Cecum
Chromatography, Gas
Chromatography, High Pressure Liquid
Coal Tar
Creosote
DNA Adducts
Dinitrobenzenes
Disease Models, Animal
Drug Synergism
Glucuronidase
Intestine, Large
Intestine, Small
Intestines
Liver

Source

Open in PubMed

Identifiers

PMID: 7897694
DOI: 10.1080/15287399509531962

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7897694-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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