Article
Effects of a tumour promoter, 12-0-tetradecanoyl-phorbol-13-acetate (TPA), on expression of differentiated phenotype in the chick retinal pigmented epithelial cells and on their interactions with the native basement membrane and with artificial substrata.
Differentiation; research in biological diversity - 1 Mar 1990
Opas M, Dziak E
Abstract excerpt
Chick retinal pigmented epithelial (RPE) cells grown in vitro on basement membrane matrices from the Engelbreth-Holm-Swarm tumour (BM-matrigel) do not spread, and they maintain their differentiated phenotype, most notably the heavy pigmentation. Maintenance of the differentiated phenotype by RPE...
Topics
- Animals
- Basement Membrane
- Cell Adhesion
- Cell Communication
- Cell Differentiation
- Cells, Cultured
- Chick Embryo
- Collagen
- Cytoskeleton
- Drug Combinations
- Extracellular Matrix
- Fluorescent Antibody Technique
- Laminin
- Phenotype