Article
PKA and PKC activation induces opposite glial fibrillary acidic protein (GFAP) expression and morphology changes in a glioblastoma multiform cell line of clonal origin.
Journal of neuroscience research - 1 Apr 1995
Arcuri C, Bocchini V, Guerrieri P, Fages C, Tardy M
Abstract excerpt
Possible differentiation mechanisms were investigated in a glioblastoma multiform cell line (GL15) presenting an undifferentiated phenotype with weak glial fibrillary acidic protein (GFAP) and strong vimentin (VIM) expression. Serum-free conditions induced time-dependent increases of GFAP-mRNA an...
Topics
- Blotting, Northern
- Blotting, Western
- Bucladesine
- Cell Differentiation
- Clone Cells
- Cyclic AMP-Dependent Protein Kinases
- Electrophoresis, Polyacrylamide Gel
- Enzyme Activation
- Fluorescent Antibody Technique
- Glial Fibrillary Acidic Protein
- Glioblastoma
- Humans
- Phenotype
- Protein Kinase C