Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities.

doi:10.2337/diabetes.47.3.307

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Article

Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities.

Diabetes - 1 Mar 1998

Matschinsky F M, Glaser B, Magnuson M A

Abstract excerpt

There remains a wide gap between theoretical concepts and experimental realities in the enzyme kinetics and biochemical genetics of the pancreatic beta-cell glucokinase-glucose sensor. It is the goal of present efforts in many laboratories to bridge this gap. This perspective intends to provide a timely review of this crucial aspect of research in glucose homeostasis. It deals briefly with some fundamentals of...

Topics

Animals
Diabetes Mellitus, Type 2
Glucokinase
Glucose
Humans
Islets of Langerhans
Kinetics
Mice
Mutation

Source

Open in PubMed

Identifiers

PMID: 9519733
DOI: 10.2337/diabetes.47.3.307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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